I have been studying PixInsight further and further and am starting to get the hang of how it can process calibrated data. It's gradient correction and multiple stretching alogorithms (Statistical Stretch, iHDR strech and Generalised Hyperbolic Stretch) are really impressive.
I took 3 hours of LRGB subs of 3 - 5 mins on my Williams Optics 132mm into a ZWO 1600MM-c set to 0 Celcius (and using a ZWO 7 filter wheel and ZWO focuser) - all controlled by APT 4.40.
I stacked and processed the subs and calibration frames in PI and am happy with the result with this inital data - from Bortle 6 Sydney skies.
In PI I used WBPP, Blur Xterminator (correct only) Noise Xterminator, Gradient Correction, Blur Xterminator, HDR Combine, LRGB Combine, Statistical Stretch, iHDR, Generalised Hyperbolic stretch and finally a very, very light Unsharp Mask.